How does resveratrol work chemically? like, how chemical structure relates to function in the body...? - Yahoo! Answers
How does resveratrol work chemically? like, how chemical structure relates to function in the body...? - Yahoo! Answers
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How does resveratrol work chemically like, how chemical structure relates to function in the body...
i have to write a paper about it for chem class, so my teacher is looking for how it works in the body. since its chem class, she wants the chemistry behind it, not just the biology (e.g. helping mitochondria or ant-inflammatory for arteries). any knowledge would be awesome!
3 weeks ago
(Tiebreaker)
Answers (1)
Answerer 1
Here are the findings of one study by Dr. Sinclair. This contains some of the chemical info you are looking for, but yes, such data is hard to come by.
Sinclair reported that resveratrol counteracted the detrimental effects of a high-fat diet in mice. The high fat diet was compounded by adding hydrogenated coconut oil to the standard diet; it provided 60% of energy from fat, and the mice on it consumed about 30% more calories than the mice on standard diet. Both the mice fed the standard diet and the high-fat diet plus 22 mg/kg resveratrol had a 30% lower risk of death than the mice on the high-fat diet. Gene expression analysis indicated the addition of resveratrol opposed the alteration of 144 out of 155 gene pathways changed by the high-fat diet. Insulin and glucose levels in mice on the high-fat+resveratrol diet were closer to the mice on standard diet than to the mice on the high-fat diet. However, addition of resveratrol to the high-fat diet did not change the levels of free fatty acids and cholesterol, which were much higher than in the mice on standard diet. A further study by a group of scientists, which included Sinclair, indicated that resveratrol treatment had a range of beneficial effects in elderly mice but did not increase the longevity of ad libitum-fed mice when started midlife.
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